All studies to date point towards the potential antiaging benefits of Tetrahydrocurcuminoids (THCs), both in nutritional and topical use. The Tetrahydrocurcumin (THC) was found to improve the longevity (life span) of animal in experimental models. In preliminary studies, mice that received diets containing THC (0.2%) from the age of 13 months old had survived significantly longer than the average life span (days) compared to the control mice (Kitani et al., 2007).
A recently published study showed that THCs may regulate the aging process via a pathway that includes O-type forkhead domain transcription factor (FOXO) and silent information regulator 2 (Sir2). FOXO is involved in process such as aging, oxidative response. THC was able to increase the life span of Drosophila melanogaster by attenuating the oxidative stress response and aging process via FOXO (Xiang et al., 2011).
It is evident from the rapidly evolving research that safe and versatile THCs support healthy aging and longevity. As natural metabolites of the curcuminoids, THCs presents an attractive option to supplement manufacturers seeking to revitalize their antiaging formulations.