Ali MS, Mudagal MP, Goli D. Cardioprotective effect of tetrahydrocurcumin and rutin on lipid peroxides and antioxidants in experimentally induced myocardial infarction in rats. Pharmazie. 2009; 64(2):132-6
Anand P, Thomas SG, Kunnumakkara AB, Sundaram C, Harikumar KB, Sung B, et al. Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature. Biochemical Pharmacology. 2008; 76(11):1590-611
Battino M, Bompadre S, Politi A, Fioroni M, Rubini C, Bullon P. Antioxidant status (CoQ10 and Vit. E levels) and immunohistochemical analysis of soft tissues in periodontal diseases. Biofactors. 2005; 25(1-4):213-7
Begum AN, Jones MR, Lim GP, Morihara T, Kim P, Heath DD, et al. Curcumin structure-function, bioavailability and efficacy in models of neuroinflammation and Alzheimer’s disease. J Pharamcol Exp Ther. 2008; 326(1). 196-208
Behal R, Mali AM, Gilda SS, Paradkar AR. Evaluation of local drug-delivery system containing 2% whole turmeric gel used as an adjunct to scaling and root planing in chronic periodontitis: A clinical and microbiological study. J Indian Soc Periodontol. 2011; 15(1):35-8
Chhaparwal Y, Pai, KM, Kamath, MS, Carnelio S, Chhaparwal S. Efficacy and safety of tetrahydrocurcuminoid in the treatment of oral leukoplakia: a pilot study. Asian J Pharmaceut Clin Res. 2018; 11(12):194-6
Cikrikci S, Mozioglu E, Yilmaz H. Biological activity of curcuminoids isolated from Curcuma longa. Rec Nat Prod. 2008; 2(1):19-24
Frautschy SA, Hu W, Kim P, Miller SA, Chu T, Harris-White ME, et al. Phenolic anti-inflammatory antioxidant reversal of Aβ-induced cognitive deficits and neuropathology. Neurobiol Aging. 2001; 22(6):993-1005
Hassaninasab A, Hashimoto Y, Yokotani KT and Kobayashi M. Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism. PNAS. 2011; 108(16):6615-20
Helson L, Bolger G, Majeed M, Vcelar B, Pucaj K, Matabudul D. Infusion pharmacokinetics of Lipocurc™ (liposomal curcumin) and its metabolite tetrahydrocurcumin in beagle dogs. Anticancer Res. 2012; 32(10):4365-70
Hung WL, Ho CT, Hwang LS. Inhibitory activity of natural occurring antrioxidants on thiyl radical induced trans-arachidonic acid formation. J Agric Food Chem. 2011; 59(5):1968-73
Karthikesan K, Pari L, Menon VP. Antihyperlipidemic effect of chlorogenic acid and tetrahydrocurcumin in rats subjected to diabetogenic agents. Chem Biol Interact. 2010; 188(3):643-50
Kim JM, Araki S, Kim DJ, Park CB, Takasuka N, Baba-Toriyama H, et al. Chemopreventive effects of caratenoids and Curcumins on mouse colon carcinogenesis after 1,2-dimethylhydrazine initiation. Carcinogenesis. 1998; 19(1): 81-5
Kim T and Davis J, Zhang AJ, He X, Mathews ST. Curcumin activates AMPK and suppresses gluconeogenic gene expression in hepatoma cells. Biochem Biophys Res Commun. 2009; 388(2):377-82
Kitani K, et al. The effects of tetrahydrocurcumin and green tea polyphenol on the survival of male C57BL/6 mice. Biogerontology. 2007; 8(5), 567-73
Lai CS, Wu JC, Yu SF, Badmaev V, Nagabhushanam K, Ho CT, et al. Tetrahydrocurcumin is more effective than curcumin in preventing azoxymethane-induced colon carcinogenesis. Mol Nutr Food Res. 2011;55(12):1819-28
Lau WL, Khazaeli M, Savoj J, Manekia K, Bangash M, Thakurta RG, <em>et al</em>. Dietary tetrahydrocurcumin reduces renal fibrosis and cardiac hypertrophy in 5/6 nephrectomized rats. <em>Pharmacol Res Perspect</em>. 2018; 6(2):e00385
Lenzen S, Drinkgern J, Tiedge M. Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. Free Radic Biol Med. 1996; 20(3):463-6
Majeed, et al., 1995. Curcuminoids: antioxidant phytonutrients. Sabinsa Corporation NJ. USA
Matabudul D, Pucaj K, Bolger G, Vcelar B, Majeed M, Helson L. Tissue distribution of (Lipocurc™) liposomal curcumin and tetrahydrocurcumin following two-and eight-hour infusions in beagle dogs. Anticancer Res. 2012; 32(10):4359-64
Murugan P and Pari L. Antioxidant effect of tetrahydrocurcumin in streptozotocin-nicotinamide induced diabetic rats. Life Sci. 2006; 79(18):1720-8
Murugan P and Pari L. Antioxidant effect of tetrahydrocurcumin in streptozotocin-nicotinamide induced diabetic rats. Life Sci. 2006; 79(18):1720-8
Murugan P and Pari L. Effect of Tetrahydrocurcumin on Lipid Peroxidation and Lipids in Streptozotocin-Nicotinamide-Induced Diabetic Rats. Basic Clin Pharmacol Toxicol. 2006a; 99(2):122-7
Murugan P and Pari L. Influence of Tetrahydrocurcumin on Hepatic and Renal Functional Markers and Protein Levels in Experimental Type 2 Diabetic Rats. Basic Clin Pharmacol Toxicol. 2007b; 101(4):241-5
Murugan P and Pari L. Protective role of tetrahydrocurcumin on changes in the fatty acid composition in streptozotocin-nicotinamide induced type 2 diabetic rats. J Appl Biomed. 2007a; 5:31-8
Muthumani M, Miltonprabu S. Ameliorative efficacy of tetrahydrocurcumin against arsenic induced oxidative damage, dyslipidemia and hepatic mitochondrial toxicity in rats. Chem Biol Interact. 2015; 235:95-105
Naito M, et al. The protective effects of tetrahydrocurcumin on oxidative stress in cholesterol fed rabbits. J Atheroscler Thromb. 2002; 9(5), 243-50
Novaes JT, Lillico R, Sayre CL, Nagabushnam K, Majeed M, Chen Y, et al. Disposition, metabolism and histone deacetylase and acetyltransferase inhibition activity of tetrahydrocurcumin and other curcuminoids. Pharmaceutics. 2017; 9(4):45
Okada K, Wangpoengtrakul C, Tanaka T, Toyokuni S, Uchida K, Osawa T. Curcumin and especially tetrahydrocurcumin ameliorate oxidative stress-induced renal injury in mice. J Nutr. 2001; 31, 2090-5
Pan MH, Huang TM, Lin JK. Biotransformation of curcumin through reduction and glucuronidation in mice. Drug Metab and dispos. 1999; 27(1), 486-94
Pandit S, Kim HJ, Kim JE, Jeon JG. Separation of an effective fraction from turmeric against Streptococcus mutans biofilms by the comparison of curcuminoid content and anti-acidogenic activity. Food Chem. 2011; 126(4):1565-70
Pari L and Amali DR. Protective role of Tetrahydrocurcumin (THC) an active principle of turmeric on chloroquine induced hepatotoxicity in rats. J Pharm Pharmaceut Sci. 2005; 8(1):115-23
Pari L and Murugan P. Antihyperlipidemic effect of curcumin and tetrahydrocurcumin in experimental type 2 diabetic rats. Renal failure. 2007b; 29:881-9
Pari L and Murugan P. Changes in glycoprotein components in streptozotocin–nicotinamide induced type 2 diabetes: influence of tetrahydrocurcumin from Curcuma longa. Plant Foods Hum Nutr. 2007; 62(1):25-9
Pari L and Murugan P. Effect of Tetrahydrocurcumin on blood glucose, plasma insulin and hepatic key enzymes in streptozotocin induced diabetic rats. J Basic Clin Physiol Pharmacol. 2005; 16(4):257-74
Pari L and Murugan P. Influence of tetrahydrocurcumin on tail tendon collagen contents and its properties in rats with streptozotocin-nicotinamide induced type 2 diabetes. Fundam Clin Pharmacol. 2007a; 21(6). 665-71
Pari L and Murugan P. Protective role of tetrahydrocurcumin against erythromycin estolate-induced hepatotoxicity. Pharmacol Res. 2004; 49(5):481-6
Pari L and Murugan P. Tetrahydrocurcumin prevents brain lipid peroxidation in streptozotocin-induced diabetic rats. J Med Food. 2007c;10(2):323-9
Pari L and Murugan P. Tetrahydrocurcumin: Effect on Chloroquine-Mediated Oxidative Damage in Rat Kidney. Basic Clin Pharmacol Toxicol. 2006; 99(5):329-34
Pari L, Karthikesan K, Menon VP. Comparative and combined effect of chlorogenic acid and tetrahydrocurcumin on antioxidant disparities in chemical induced experimental diabetes. Mol Cell Biochem. 2010; 341(1-2):109-17
Portes E, Gardrat C, Castellan A. A comparative study on the antioxidant properties of tetrahydrocurcuminoids and curcuminoids. Tetrahedron. 2007; 63, 9092-9
Prabhu PR, Hegde K, Shabaraya AR and Rao MNA. Scavenging potential of reactive oxygen species by Tetra-hydrocurcumin. Journal of Applied Pharmaceutical Science. 2011; 01(05):114-118
Ramakrishnan R, Elangovan P, Pari L. Protective role of tetrahydrocurcumin: an active polyphenolic curcuminoid on cadmium-induced oxidative damage in rats. Appl Biochem Biotechnol. 2017; 183(1):51-69
Robertson RP. Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes, J Biol Chem.2004; 279(41):42351-4
Somparn P, Phisalaphong C, Nakornchai S, Unchern S, Morales NP. Comparative antioxidant activities of curcumin and its demethoxy and hydrogenated derivatives. Biol Pharm Bull. 2007; 30(1), 74-8
Stumvoll M, et al. Clinical features of insulin resistance and beta cell dysfunction and the relationship to type 2 diabetes. Clin Lab Med. 2001; 21(1):31-51
Unpublished Results from Rutgers, The State University of New Jersey and Sabinsa Corporation
West IC. Radicals and oxidative stress in diabetes. Diabetic Med. 2000: 17, 171-180
Wu JC, Lai CS, Badmaev V, Nagabhushanam K, Ho CT, Pan MH. Tetrahydrocurcumin, a major metabolite of curcumin, induced autophagic cell death through coordinative modulation of PI3K/Akt-mTOR and MAPK signaling pathways in human leukemia HL-60 cells. Mol Nutr Food Res. 2011;55(11):1646-54
Xiang L, Osawa T, Yokozawa T. Tetrahydrocurcumin extends life span and inhibits the oxidative stress response by regulating the FOXO forkhead transcription factor. Aging. 2011;3(11):1098-1109
Yoysungnoen P, Wirachwong P, Changtam C, Suksamrarn A, Patumraj S. Anti-cancer and anti-angiogenic effects of curcumin and tetrahydrocurcumin on implanted hepatocellular carcinoma in nude mice. World J Gastroenterol. 2008; 14(13):2003-9
Zhang ZB, Luo DD, Xie JH, Xian YF, Lai ZQ, Liu YH, et al. Curcumin’s metabolites, Tetrahydrocurcumin and octahydrocurcumin, possess superior anti-inflammatory effects in vivo through suppression of TAK1-NF- κB pathway. Front Pharmacol. 2018; 9: 1181