Tetrahydrocurcumin is more effective than curcumin in preventing azoxymethane-induced colon toxicity

Tetrahydrocurcumin (THC), a major metabolite of curcumin derived from turmeric, has been the subject of research demonstrating its potent activity in animal models. Specifically, studies on animals have shown that THC has significant effects in inhibiting tumor initiation induced by azoxymethane (AOM), highlighting its anti-carcinogenic potential in these models. Further research into the anti-inflammatory and anti-carcinogenic activities of curcumin and its derivatives, including THC, has revealed that the action mechanisms involved are complex. Notably, tetrahydrocurcumin emerges as a major active metabolite in mice, suggesting its important role when curcumin is administered in these animal studies.

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